In the cerebral cortex, extrinsic and intrinsic excitatory glutamatergic pathways terminate on principal glutamatergic neurons and local inhibitory GABAergic interneurons. Activation of these pathways ...

Scientists have discovered that T cell receptors activate through a hidden spring-like motion that had never been seen before. This breakthrough may help explain why immunotherapy works for some ...

A bitter taste has always been considered a warning signal, devoted to protecting us from ingesting potentially harmful ...

Roche reported positive Phase II topline data showing that its once-weekly dual glucagon-like peptide-1 and glucose-dependent ...

The behaviour of a receptor protein can be influenced by the presence of certain lipids in the membrane it is embedded in.

Prostaglandin E 2 (PGE 2), a bioactive lipid derived from arachidonic acid, mediates a broad range of physiological processes through four G protein-coupled receptor (GPCR) subtypes: EP1–EP4. While ...

Researchers at the University of North Carolina (UNC) at Chapel Hill School of Medicine have revealed the detailed structure of the bitter taste receptor, a protein called TAS2R14, and have shown ...

New research suggests that δ-receptor agonists regulate intestinal motility and relieve abdominal pain in a mouse model of irritable bowel syndrome, potentially offering a novel CNS-targeted treatment ...

Epidermal growth factor receptor (EGFR) signaling in the tissue around oral cancers both increases nerve sensitivity and ...