Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal ...
Unrepaired DNA-protein crosslinks (DPCs) – highly toxic tangles of protein and DNA – cause a process that leads to premature ...
New research sheds light on how cells repair damaged DNA. For the first time, the team has mapped the activity of repair proteins in individual human cells. The study demonstrates how these proteins ...
Knowing how human DNA changes over generations is essential to estimating genetic disease risks and understanding how we evolved. But some of the most changeable regions of our DNA have been ...
A new study shows that cancer damages its own DNA by pushing key genes to work too hard. Researchers found that the most ...
Objectives Understanding the molecular changes in the preclinical synovium is crucial for identifying factors that drive ...
A powerful new discovery reveals that Nup98 a protein once thought to only ferry molecules through the nucleus plays a vital role in safeguarding the most vulnerable areas of DNA. By forming ...
DNA repair is essential for the maintenance of genomic stability and its failure can lead to human disease. Various DNA repair systems exist, such as base excision repair, nucleotide excision repair, ...
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